Research by the University of North Carolina at Chapel Hill and an international team will track the toxic effects of common consumer products on the gut flora and induce colitis.
New studies done in mice show exactly that triclosan, an antibacterial agent found in toothpaste, toys, and thousands of other products, can cause intestinal inflammation.
An international team of researchers led by the University of North Carolina at Chapel Hill, The University of Massachusetts Amherst and the University of Hong Kong Baptist have identified the bacteria that cause the harmful effects of triclosan, and even certain enzymes. In addition, studies in mice suggest that these bacterial enzymes can prevent intestinal damage.
The survey results have been published at Nature Communications..
“Identifying the causative organism has the potential to develop new approaches for the diagnosis, prevention and treatment of inflammatory bowel disease,” said UNC Chapel Hill University of Arts and Sciences and UNC Professor of Chemistry and Microbiology. Research author Matthew Redimbo said. School of medicine.
Previous studies have shown toxicity of triclosan, but a new study looks closely at the changes caused by the microscopic population of the intestine.
Researchers have linked certain gut microbiota enzymes, especially the gut microbiota beta-glucuronidase (GUS) protein, to triclosan, which drives triclosan to cause catastrophic intestinal disruption.
The team knew which bacterial protein was the cause and used a microbiota-targeted inhibitor to block triclosan treatment in the intestine. Blocking this process in mice prevented damage to the colon and symptoms of colitis, a type of inflammatory bowel disease.
This study provides new clues about the management of IBD in the growing number of people diagnosed with this disease. IBD can be managed for a long period of time and seems to just burn out of nowhere.
The authors of the study suggest that we need to better understand the effects of environmental chemicals on gut health.
Triclosan was widely available in antibacterial soaps sold to consumers. However, in 2016, the Food and Drug Administration ordered removal from hand-washing products used in home and hospital environments because of concerns that it would contribute to more resistant bacteria.
However, triclosan is ubiquitous as an ingredient added to cosmetics, yoga mats, and other athletic clothing and gear to reduce bacterial contamination. It is also known to prevent periodontitis and is routinely used in many toothpastes with FDA approval.
Triclosan appears to be easily absorbed into the gastrointestinal tract, leading the author of the study, “The safety of triclosan and related compounds needs to be revisited given the potential for intestinal damage.” I am writing.
Reference: “Microbial enzymes induce colitis by reactivating triclosan in the gastrointestinal tract of mice” Jianan Zhang, Morgan E. Walker, Katherine Z. Sanidad, Hongna Zhang, Yanshan Liang, Ermin Zhao, Katherine Chacon -Vargas, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Guangqiang Wang, Joshua B. Simpson, Parth B. Jariwala, Violet V. Beaty, Jun Yang, Haixia Yang, Anand Panigrahy, Lisa M. Minter, Daeyoung Kim, John G. Gibbons, LinShu Liu, Zhengze Li, Hang Xiao, Valentina Borlandelli, Hermen S. Overkleeft, Erica W. Cloer, Michael B. Major, Dennis Goldfarb, Zongwei Cai, Matthew R. Redinbo, Guodong Zhang, January 10, 2022 Day, Nature Communications..
DOI: 10.1038 / s41467-021-27762-y
The National Institutes of Health was funded by the Hong Kong Research Grants Council and the National Science Foundation through grants to several authors. “Microbial enzymes induce colitis by reactivating triclosan in the gastrointestinal tract of mice.”